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Uricase-deficient larval zebrafish with elevated urate levels demonstrate suppressed acute inflammatory response to monosodium urate crystals and prolonged crystal persistence

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When controlling for NAA levels as a control for neuronal integrity, GABA levels in ACC become significantly lower in OCD compared with the healthy subjects (ANCOVA F -test (1, 57) = 4.55, p = 0.03, p -FDR = 0.04, p 2 = 0.074, 95% CI[0.012, 0.35]), whereas, OCC Glu level differences become non-significant ( p = 0.20)